Tetrapyrroles and derivatives
Abcam Tetrahydrouridine, cytidine deaminase inhibitor, 25MG
MW 248.23 Da, Purity >80%. Competitive cytidine deaminase inhibitor (IC₅₀= 152 μM). Modulates antiproliferative effects. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam QNZ, NF-kB inhibitor, 1MG
MW 358.4 Da, Purity >98%. Potent, selective NF-kB inhibitor (IC₅₀ = 11 nM). Inhibits LPS-induced TNFα production (IC₅₀ = 7 nM). Reduces edema in inflammation in vivo..
The product is subject to the following: Abcam Restricted Use Statement
Abcam Bisindolylmaleimide II, PKC inhibitor, 1MG
MW 438.5 Da, Purity >97%. Potent, selective ATP-competitive PKC inhibitor (IC₅₀ values are 0.01, 0.75 and 2 μM for PKC, phosphorylase kinase and PKA respectively). Potent noncompetitive nAChR antagonist (IC₅₀ = 0.03 μM, catecholamine secretion in nicotine-stimulated PC-12 cells). Shows more potent antinicotinic effects than Bisindolylmaleimide IV (ab144208) and V (ab144205). Induces apoptosis and shows antiproliferative effects.
The product is subject to the following: Abcam Restricted Use Statement
Abcam EMD 386088 hydrochloride, 5-HT6 agonist, 10MG
MW 283.2 Da, Purity >98%. Potent 5-HT6 agonist (IC50 = 7.4 nM in 3H-LSD binding and EC50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC50 values are 110 (5-HT1D), 180 (5-HT1B), 240 (5-HT2A), 450 (5-HT2C), 620 (5-HT4), 660 (5-HT1A ) and 3000 nM (5-HT7)). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM). Impairs memory *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CL-316243 disodium salt, adrenergic-beta3 receptor agonist, 25MG
MW 465.8 Da, Purity >99%. Selective adrenergic-β3 receptor agonist. Induces adipose tissue remodelling in rat. Hypoglycemic agent. Active *in vivo* and *in vitro*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Nocodazole, Microtubule inhibitor, 25MG
MW 301.32 Da, Purity >98%. Microtubule inhibitor. Rapidly depolymerises microtubules in vivo and inhibits tubulin polymerisation in vitro. Inhibits mitosis. Also reduces stem cell pluripotency factors Oct 4 and Nanog.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Undecylprodigiosin, Apoptotic and anticancer agent, 250UG
MW 393.6 Da, Purity >93%. Apoptotic and anticancer agent. Selectively induces p53-independant apoptosis in cancer cells. Induces G2/M cell cycle arrest and shows antiproliferative effects. Shows antimalarial and antibactieral effects in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Phthalocyanine | 574-93-6 | 98.0% | 1 G
Phthalocyanine is a macrocyclic organic photosensitizer and dye supplied as a solid for research use. It is employed in photodynamic studies, antibacterial photoinactivation research, pigments, and materials science applications.
- Photosensitizer for photodynamic and antibacterial research.
- Solid form suitable for storage and formulation.
- Stable macrocyclic structure; CAS 574-93-6; molecular weight 514.54 g/mol.
- Recommended storage: 4°C, protect from light; in solvent: -80°C (6 months) or -20°C (1 month) under inert atmosphere.
- Available in small research pack quantities.
Abcam GR 127935 hydrochloride, 5-HT1B/1D receptor antagonist, 50MG
MW 534.06 g/mol, Purity >97%. Potent and selective 5-HT₁B/₁D receptor antagonist (pKi = 8.5 for both 5-HT₁D in rat and 5-HT₁D in guinea pig). 100-fold selectivity over 5-HT₁A, 5-HT₁E, and 5-HT₂C. Displays centrally mediated effects upon systemic administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dorsomorphin (Compound C), AMP-kinase inhibitor, 50MG
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 408124, non-peptide O x 1 antagonist, 10MG
MW 356.4 Da, Purity >97%. Selective, non-peptide orexin receptor 1 (OX1) antagonist (Ki = 26.9 nM). Displays 50-fold selectivity over OX2 (Kb values are 21.7 and 1405 nM for OX1 and OX2, respectively).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dorsomorphin (Compound C), AMP-kinase inhibitor, 10MG
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
The product is subject to the following: Abcam Restricted Use Statement
Abcam AMD3100 octahydrochloride, C x CR4 antagonist, 10MG
MW 794.5 Da, Purity >99%. Plerixafor (hydrochloride) is a macrocyclic compound that acts as an irreversible antagonist against the binding of CXCR4 with its ligand, SDF-1 (CXCL12). It suppresses infection by HIV with an IC₅₀ value of 1-10 ng/ml with selectivity toward CXCR4-tropic virus. Plerixafor mobilizes hematopoietic stem and progenitor cells for transplant better than G-CSF alone. It also increases T-cell trafficking in the blood and spleen as well as the central nervous system. Plerixafor regulates the growth of primary and metastic breast cancer cells and inhibits dissemination of ovarian carcinoma cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Genipin, Cell-permeable uncoupling protein 2 inhibitor, 100MG
MW 226.23 g/mol, Purity >99%. Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Endothelin-1 (human, porcine), Vasoconstrictor peptide, 100UG
MW 2491.9 Da. Endothelin-1 (human, porcine), Vasoconstrictor peptide. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement