Tetrapyrroles and derivatives
Abcam Verteporfin (Visudyne), Benzoporphyrin derivative, 25MG
MW 718.8 Da, Purity >96%. Benzoporphyrin derivative. Antiangiogenic agent. Produces ROS on stimulation with nonthermal red light in the presence of oxygen. Prevents corneal neovascularization and shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 242084 hydrochloride, 5-HT2C antagonist, 10MG
MW 431.3 Da, Purity >98%. Potent, selective 5-HT2C antagonist (pKi values are 9 (5-HT2C), 7 (5-HT2B), 6.8 (5-HT2A), 6.4 (5-HT1A), 6.4 (5-HT1B), 6.4 (5-HT1D), 6 (5-HT1E), <6.1 (5-HT1F), <5.5 (5-HT4), 6 (5-HT6), 6.1 (5-HT7), 6.2 (D2), 6.2 (D3) and <5 (α1)). Blood-brain barrier permeable. Anxiolytic activity *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Cytochalasin D, actin polymerization inhibitor, 1MG
MW 507.6 Da, Purity >98%. Cytochalasin D, actin polymerization inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist, 25MG
MW 283.41 Da, Purity >99%. Selective protease-activated receptor 2 (PAR2) antagonist (IC₅₀ = 1.2 mM). Anti-inflamatory agent. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Abcam P5091, USP-7 inhibitor, 25MG
MW 348.2 Da, Purity >98%. Potent, selective and cell-permeable USP-7 inhibitor (EC₅₀ = 4.2 μM). Induces apoptosis in cancer cells in vitro. Antiangiogenic and antitumor agent. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Prodigiosin, apoptotic agent, 250UG
MW 323.4 Da, Purity >95%. Potent apoptotic agent. Antibiotic agent. Induces caspase-dependent apoptosis. Inhibits mTORC1 and mTORC2. Reactivates p53. Inhibits iNOS expression. Shows anti-ischemic and antimalarial effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam U-69593, kappa1-opioid receptor agonist, 5MG
MW 356.5 Da, Purity >99%. Potent, selective κ1-opioid receptor agonist (EC50 = 80-109 nM). Active *in vivo*. Antinociceptive.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 4-Thiouridine, RNA synthesis inhibitor, 5MG
MW 260.27 Da, Purity >99%. Ribonucleoside (Uridine ab143255) analog. Antisense agent. RNA synthesis inhibitor. Modifies oligos slated for RNA. Induces p53 and inhibits proliferation. Metabolically labels RNA for stability studies.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (Arg8)-Vasopressin (AVP), Vasopressin receptor agonist, 1MG
MW 1084.2 Da, Purity >95%. (Arg8)-Vasopressin (AVP), Vasopressin receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 5-Aza-2'-deo x ycytidine (Decitabine), DNMT1 inhibitor, 10MG
MW 228.21 Da, Purity >99%. Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC₅₀ = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Zinc phthalocyanine | 14320-04-8 | 98.0% | 577.90 | 5 G
Zinc phthalocyanine (ZnPc) is commonly applied in industry as catalysts and photoconductors, and in biomedical fields for photodynamic therapy (PDT). It can be used to photooxidise cyclohexane and is promising for research in solar-cell applications.
- Inhibits the growth of cancer cells Kyse-140 and OE-33 with IC50 values of 1.41 μM and 3.35 μM respectively (1-10 μM, 24 h).
- Acts as a photosensitizer that is taken up by cancer cells and produces Reactive Oxygen Species (ROS) under specific wavelength light irradiation (694 nm).
- Impairs mitochondrial membrane integrity, activates caspase-3, and induces apoptosis.
- Causes long-term damage to the microvascular network of the CAM (10 μM, topical application, single dose).
- Exhibits antitumor activity in chick chorioallantoic membrane models.
Abcam Desmethyl YM298198 hydrochloride, Analogue of mGlu1 antagonist YM298198, 50MG
MW 364.9 Da, Purity >99%. Derivative of mGlu1 antagonist YM298198 (ab120015). Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam ODQ, NO-sensitive guanylyl cyclase inhibitor, 50MG
MW 187.15 Da, Purity >99%. Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam WAY-100635 maleate, 5-HT1A receptor antagonist, 10MG
MW 538.6 Da, Purity >98%. Potent, selective, silent 5-HT1A receptor antagonist (IC50 = 1.35 nM). Displays >100-fold selectivity for 5-HT1Arelative to a range of other CNS receptors including other 5-HT subtypes, adrenoceptors, dopamine, GABA, histamine and ion channels. Binds selectively to rodent brain 5-HT1A receptors *in vivo* (iv admin). Unlike WAY100135, WAY100635 displays no partial agonist activity in the ventral hippocampus of rats.
The product is subject to the following: Abcam Restricted Use Statement
Abcam UDP-glucose, Highly P2Y14 agonist, 100MG
MW 610.27 Da. Highly potent, endogenous P2Y14 agonist (EC50 = 82 nM). Involved in modulation of gastric function. UDP also available (ab120383).
The product is subject to the following: Abcam Restricted Use Statement